Cryptic crossword clue
To drink spiked gin is depressing 7

The most common and most likely answer to this crossword clue is the 7 letter word DOWNING

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DOWNING mean?

DOWNING verb
  1. To knock (someone or something) down; to cause to come down, to fell.
  2. To lower; to put (something) down.
  3. To defeat; to overpower.
  4. To disparage, to put down.
  5. To go or come down; to descend.
  6. To drink or swallow, especially without stopping before the vessel containing the liquid is empty.
  7. To render (the ball) dead, typically by touching the ground while in possession.
  8. (pocket billiards) To sink (a ball) into a hole or pocket.
DOWNING verb
  1. To cover, ornament, line, or stuff with down.
DOWNING noun
  1. An occasion on which something is downed.
  2. A defeat.

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