The most common and most likely answer to this crossword clue is the 7 letter word UNHINGE
U
N
H
I
N
G
E
More clues leading to the result UNHINGE
- Errant knight in huge trouble
- Dement having broken machine gun with no weather protection
- Create imbalance painting house anew — but not, strangely, patios
- Make psycho release the door?
- Drive mad in huge complex around noon
- Ensure door can’t swing open when you drive round the bend
- International body’s pivotal point to make slightly mad
- Huge inn demolished to bring about mental breakdown
- To drive someone mad, crazy Hun gets elected going backwards, for example
- Rattle may stop gate swinging
Buddy explains!

The straight part
We know that "To drive someone mad" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case to drive someone mad = unhinge.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does UNHINGE mean?
UNHINGE verb- To remove the leaf of a door or a window from its supporting hinges.
- To mentally disturb.