Cryptic crossword clue
To isolate some men is legitimate 6

The most common and most likely answer to this crossword clue is the 6 letter word ENISLE

I've seen this crossword clue in The Guardian
E
N
I
S
L
E

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ENISLE mean?

ENISLE verb
  1. To make into an island.
  2. (by extension) To isolate.

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