Cryptic crossword clue
To operate, holding after start 5

The most common and most likely answer to this crossword clue is the 5 letter word ENURE

E
N
U
R
E

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ENURE mean?

ENURE verb
  1. To inure; to make accustomed or desensitized to something unpleasant due to constant exposure.
  2. To take effect, to be operative; used with to.

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