Cryptic crossword clue
To play, I set up soccer for those who dislike union 12

The most common and most likely answer to this crossword clue is the 12 letter word EUROSCEPTICS

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "those who dislike union" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case those who dislike union = eurosceptics.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EUROSCEPTICS mean?

EUROSCEPTICS noun
  1. One who is sceptical of European integration, such as the EEC, the EC, the EP, the EU, the Euro, etc.

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