Cryptic crossword clue
Too satisfied with firm’s first Manchester location not being empty 10

The most common and most likely answer to this crossword clue is the 10 letter word COMPLACENT

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Buddy explains!

The straight part
We know that "Too satisfied" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case too satisfied = complacent.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does COMPLACENT mean?

COMPLACENT adjective
  1. Uncritically satisfied with oneself or one's achievements; smug.
  2. Apathetic with regard to an apparent need or problem.

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