Cryptic crossword clue
Topless Brenda flinging such a skirt — it gets the pulse racing 10

The most common and most likely answer to this crossword clue is the 10 letter word ADRENALINE

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Buddy explains!

The straight part
We know that "it gets the pulse racing" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case it gets the pulse racing = adrenaline.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ADRENALINE mean?

ADRENALINE noun
  1. Epinephrine, the hormone and neurotransmitter.

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