The most common and most likely answer to this crossword clue is the 2 plus 1 plus 4 plus 4 letter word IN A FLAT SPIN
I've seen this crossword clue in The Guardian
I
N
A
F
L
A
T
S
P
I
N
Buddy explains!
The straight part
We know that "Totally flustered" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case totally flustered = in a flat spin.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.