Cryptic crossword clue
Tours street, then finally off: adieu, all feel empty with sorrow 8

The most common and most likely answer to this crossword clue is the 8 letter word RUEFULLY

I've seen this crossword clue in The Guardian
R
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Buddy explains!

The straight part
We know that "with sorrow" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case with sorrow = ruefully.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RUEFULLY mean?

RUEFULLY adverb
  1. In a rueful manner; causing, feeling or expressing regret or sorrow.

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