Cryptic crossword clue
Trail involved great slog with lack of oxygen 8

The most common and most likely answer to this crossword clue is the 8 letter word STRAGGLE

S
T
R
A
G
G
L
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Buddy explains!

The straight part
We know that "Trail" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case trail = straggle.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does STRAGGLE mean?

STRAGGLE noun
  1. An irregular, spread-out group.
  2. An outlier; something that has strayed beyond the normal limits.
STRAGGLE verb
  1. To stray from the road, course or line of march.
  2. To wander about; ramble.
  3. To spread at irregular intervals.
  4. To escape or stretch beyond proper limits, as the branches of a plant; to spread widely apart; to shoot too far or widely in growth.
  5. To be dispersed or separated; to occur at intervals.

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