Cryptic crossword clue
Transforming gradual series of improvements in yeast 15

The most common and most likely answer to this crossword clue is the 15 letter word REVOLUTIONISING

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Buddy explains!

The straight part
We know that "Transforming" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case transforming = revolutionising.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does REVOLUTIONISING mean?

REVOLUTIONISING verb
  1. To change radically or significantly, as in a revolution.

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