Cryptic crossword clue
Transposition requiring extremes of effort in mental discipline 10

The most common and most likely answer to this crossword clue is the 10 letter word METATHESIS

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Buddy explains!

The straight part
We know that "Transposition/Transposition" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case transposition/transposition = metathesis.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does METATHESIS mean?

METATHESIS noun
  1. The transposition of letters, syllables or sounds within a word, such as in ask as /æks/.
  2. The double decomposition of inorganic salts.
  3. The breaking and reforming of double bonds in olefins in which substituent groups are swapped.

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