The most common and most likely answer to this crossword clue is the 15 letter word ANTIDEPRESSANTS
I've seen this crossword clue in The Guardian
A
N
T
I
D
E
P
R
E
S
S
A
N
T
S
More clues leading to the result ANTIDEPRESSANTS
- They pick up article by current media workers
- Treat sadness with pills primarily in jars?
- They alleviate misery of print workers after hostile journalist turns up
- Some pills worker and I push down soldiers
- Pain starts and needs to be dealt with — the answer must be drugs
- Worker ID badge finally leads to iron-workers' drugs
Buddy explains!
The straight part
We know that "Treat sadness with pills primarily in jars" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case treat sadness with pills primarily in jars = antidepressants.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ANTIDEPRESSANTS mean?
ANTIDEPRESSANTS noun- An agent that prevents or counteracts depression.