Cryptic crossword clue
Tree frog first excluded from major taxonomic groups 4

The most common and most likely answer to this crossword clue is the 4 letter word HYLA

H
Y
L
A

Buddy explains!

The straight part
We know that "Tree frog" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case tree frog = hyla.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HYLA mean?

HYLA noun
  1. A tree frog of the genus Hyla.
HYLA noun
  1. Matter
  2. The first matter of the cosmos, from which the four elements arose, according to the doctrines of Empedocles and Aristotle.

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