Cryptic crossword clue
Tried with difficulty to get guys to agree, causing harm 13

The most common and most likely answer to this crossword clue is the 13 letter word DETRIMENTALLY

D
E
T
R
I
M
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N
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A
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Y

Buddy explains!

The straight part
We know that "causing harm" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case causing harm = detrimentally.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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