Cryptic crossword clue
Trouble as Academy’s place in draw is taken by University 6

The most common and most likely answer to this crossword clue is the 6 letter word RUFFLE

R
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F
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The straight part
We know that "Trouble" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case trouble = ruffle.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RUFFLE mean?

RUFFLE noun
  1. Any gathered or curled strip of fabric added as trim or decoration.
  2. Disturbance; agitation; commotion.
  3. A low, vibrating beat of a drum, quieter than a roll; a ruff.
  4. The connected series of large egg capsules, or oothecae, of several species of American marine gastropods of the genus Fulgur.
RUFFLE verb
  1. To make a ruffle in; to curl or flute, as an edge of fabric.
  2. To disturb; especially, to cause to flutter.
  3. To grow rough, boisterous, or turbulent.
  4. To become disordered; to play loosely; to flutter.
  5. To be rough; to jar; to be in contention; hence, to put on airs; to swagger.
  6. To make into a ruff; to draw or contract into puckers, plaits, or folds; to wrinkle.
  7. To erect in a ruff, as feathers.
  8. To beat with the ruff or ruffle, as a drum.
  9. To throw together in a disorderly manner.

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