The most common and most likely answer to this crossword clue is the 11 letter word WORLD-WEARY
I've seen this crossword clue in Independent
W
O
R
L
D
-
W
E
A
R
Y
Buddy explains!
The straight part
We know that "tired of life" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case tired of life = world-weary.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does WORLD-WEARY mean?
WORLD-WEARY adjective- Tired of the ways of the world; feeling apathetic or cynical due to one's life experiences.
- Bored with life.