Cryptic crossword clue
Tsetses flying in groups of 6 7

The most common and most likely answer to this crossword clue is the 7 letter word SESTETS

I've seen this crossword clue in The Guardian
S
E
S
T
E
T
S

Buddy explains!

The straight part
We know that "groups of 6" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case groups of 6 = sestets.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SESTETS mean?

SESTETS noun
  1. A piece of music composed for six voices or six instruments; a sextet or sestuor.
  2. The last six lines of a sonnet, forming two stanzas of three lines each.

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