Cryptic crossword clue
Tube leaving Victoria empty first thing on Sunday 3

The most common and most likely answer to this crossword clue is the 3 letter word VAS

I've seen this crossword clue in Financial Times
V
A
S

Buddy explains!

The straight part
We know that "Tube" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case tube = vas.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does VAS mean?

VAS noun
  1. A vessel or duct transporting any bodily fluid, such as blood, lymph, chyle, or semen.
  2. (specifically) The vas deferens.

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