Cryptic crossword clue
Tumour resulting from mutation of a mole means English sun is ignored 8

The most common and most likely answer to this crossword clue is the 8 letter word MELANOMA

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The cryptic/wordplay part
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What does MELANOMA mean?

MELANOMA noun
  1. A dark-pigmented, usually malignant tumor arising from a melanocyte and occurring most commonly in the skin.

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