Cryptic crossword clue
Twelve heading east – uninhabited spot contains ——? 5

The most common and most likely answer to this crossword clue is the 6 letter word NO-ONE

N
O
-
O
N
E


Buddy explains!

The straight part
We know that "——" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case —— = no-one.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NO-ONE mean?

NO-ONE pronoun
  1. Used in contrast to anyone, someone or everyone: not one person; nobody.

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