Cryptic crossword clue
Twenty, on leaving Guinea, acquiring horse? 5

The most common and most likely answer to this crossword clue is the 5 letter word EQUID

I've seen this crossword clue in The Times
E
Q
U
I
D

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The straight part
We know that "horse" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case horse = equid.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EQUID mean?

EQUID noun
  1. Any animal of the taxonomic family Equidae, including any equine (horse, zebra, ass, mule, etc.)

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