Cryptic crossword clue
Twigs evil must finally change 6

The most common and most likely answer to this crossword clue is the 6 letter word WICKER

I've seen this crossword clue in The Guardian
W
I
C
K
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R


Buddy explains!

The straight part
We know that "Twigs" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case twigs = wicker.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does WICKER mean?

WICKER noun
  1. A flexible branch or twig of a plant such as willow, used in weaving baskets and furniture
  2. Wickerwork.
WICKER adjective
  1. Made of wickerwork.

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