The most common and most likely answer to this crossword clue is the 5 letter word TWEAK
I've seen this crossword clue in The Times
T
W
E
A
K
More clues leading to the result TWEAK
- Trader’s tip diluted small change
- Slightly adjust end of saw penetrating wood
- Adjust time without conviction
- Twist is feeble after tango
- Adjust wide timber frames
- Slightly adjust weight in hard timber
- Exhausted after tango and twist
- Tons lacking power to make changes
- Make adjustments to the bottom of chainsaw when cutting wood
- Golden Brown? Bit of wisdom in that tune
Buddy explains!

The straight part
We know that "Twist" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case twist = tweak.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TWEAK mean?
TWEAK noun- A sharp pinch or jerk; a twist or twitch.
- A slight adjustment or modification.
- Trouble; distress; tweag.
- A prostitute.
- An additional input to a block cipher, used in conjunction with the key to select the permutation computed by the cipher.
- To pinch and pull with a sudden jerk and twist; to twitch.
- To adjust slightly; to fine-tune.
- To twit or tease.
- To abuse methamphetamines, especially crystal meth.
- To exhibit symptoms of methamphetamine abuse, such as extreme nervousness, compulsiveness, erratic motion, excitability; possibly a blend of twitch and freak.
- To exhibit extreme nervousness, evasiveness when confronted by law enforcement or other authority (e.g., customs agents, border patrol, teacher, etc.), mimicking methamphetamine abuse symptoms.