The most common and most likely answer to this crossword clue is the 6 letter word ORPHAN
I've seen this crossword clue in The Times
O
R
P
H
A
N
More clues leading to the result ORPHAN
- Parentless child frequently so pronounced by some
- Lonely type getting up behind Chinese people
- Harp on about deprived child?
- Twist, say, regularly in speech as picked up by some?
- Mobilised Oprah’s own Foundation for parentless child
- Child that’s left hospital: men criticise nurses
- Harp on about Annie, say
- Solitary individual old pub’s managed without
- Harry Potter possibly is in favour of turning up at Hollywood awards night, initially
- Twist maybe or, so it’s said, early parts of fandango
Buddy explains!
The straight part
We know that "Twist, say" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case twist, say = orphan.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ORPHAN mean?
ORPHAN noun- A person, especially a minor, both or (rarely) one of whose parents have died.
- A person, especially a minor, whose parents have permanently abandoned them.
- A young animal with no mother.
- Anything that is unsupported, as by its source, provider or caretaker, by reason of the supporter's demise or decision to abandon.
- A single line of type, beginning a paragraph, at the bottom of a column or page.
- Any unreferenced object.
- To deprive of parents (used almost exclusively in the passive)
- To make unavailable, as by removing the last remaining pointer or reference to.
- Deprived of parents (also orphaned).
- (by extension) Remaining after the removal of some form of support.