Cryptic crossword clue
Twitcher, half dead, in grip of stress 6

The most common and most likely answer to this crossword clue is the 6 letter word BIRDER

B
I
R
D
E
R

Buddy explains!

The straight part
We know that "Twitcher" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case twitcher = birder.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does BIRDER mean?

BIRDER noun
  1. A birdwatcher.
  2. A person who hunts birds.

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