Cryptic crossword clue
Unable to move having imbibed last of potent drink — get knotted! 10

The most common and most likely answer to this crossword clue is the 10 letter word INTERTWINE

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Buddy explains!

The straight part
We know that "get knotted" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case get knotted = intertwine.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INTERTWINE mean?

INTERTWINE verb
  1. To twine something together.
  2. To become twined together.

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