Cryptic crossword clue
Unbuttoned daughter in college departs 5

The most common and most likely answer to this crossword clue is the 5 letter word UNDID

I've seen this crossword clue in The Times
U
N
D
I
D

Buddy explains!

The straight part
We know that "Unbuttoned" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case unbuttoned = undid.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does UNDID mean?

UNDID verb
  1. To reverse the effects of an action.
  2. To unfasten.
  3. To impoverish or ruin, as in reputation; to cause the downfall of.

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