Cryptic crossword clue
Unclean boxes Picaroon overturned? That’s rash 8

The most common and most likely answer to this crossword clue is the 8 letter word ERUPTION

I've seen this crossword clue in The Guardian
E
R
U
P
T
I
O
N

Buddy explains!

The straight part
We know that "rash" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case rash = eruption.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ERUPTION mean?

ERUPTION noun
  1. A violent ejection, such as the spurting out of lava from a volcano.
  2. A sudden release of pressure or tension.
  3. An infection of the skin resulting in a rash or blemishing.

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