The most common and most likely answer to this crossword clue is the 7 letter word DILUENT
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The straight part
We know that "agent to weaken" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case agent to weaken = diluent.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DILUENT mean?
DILUENT noun- That which dilutes.
- A solvent or other liquid preparation used to dilute a sample prior to testing.
- An agent used for effecting dilution of the blood; a weak drink.
- Diluting; making thinner or weaker by admixture, especially of water.