The most common and most likely answer to this crossword clue is the 4 letter word PANT
I've seen this crossword clue in Financial Times
P
A
N
T
Buddy explains!
The straight part
We know that "can make you this" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case can make you this = pant.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PANT mean?
PANT noun- A quick breathing; a catching of the breath; a gasp.
- Eager longing.
- A violent palpitation of the heart.
- To breathe quickly or in a labored manner, as after exertion or from eagerness or excitement; to respire with heaving of the breast; to gasp.
- To long eagerly; to desire earnestly.
- To long for (something); to be eager for (something).
- Of the heart, to beat with unnatural violence or rapidity; to palpitate.
- To sigh; to flutter; to languish.
- To heave, as the breast.
- To bulge and shrink successively, of iron hulls, etc.
- A pair of pants (trousers or underpants).
- (used attributively as a modifier) Of or relating to pants.
- (Scotland and northeast England) Any public drinking fountain.