Cryptic crossword clue
Unexpected reactions to drug 9

The most common and most likely answer to this crossword clue is the 9 letter word NARCOTISE

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does NARCOTISE mean?

NARCOTISE verb
  1. To use a narcotic in order to make (someone) drowsy or insensible; to anesthetize, to drug.
  2. To dull the senses of (a person, place etc.).
  3. To make into a narcotic.

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