Cryptic crossword clue
Unfortunately fails to get home in East End

The most common and most likely answer to this crossword clue is the 8 letter word FINALISE

I've seen this crossword clue in The Guardian
F
I
N
A
L
I
S
E

Buddy explains!

The straight part
We know that "End" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case end = finalise.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does FINALISE mean?

FINALISE verb
  1. To make final or firm; to finish or complete.
  2. To prepare (an object) for garbage collection by calling its finalizer.

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