The most common and most likely answer to this crossword clue is the 6 letter word PAUPER
I've seen this crossword clue in Independent
P
A
U
P
E
R
More clues leading to the result PAUPER
- Poor man’s university featuring in the Sun?
- Down-and-out old man given drug with heart conking out
- One has very little uranium in organ
- University dissertation’s about down-and-out
- Very poor person for all to see in tabloid?
- Trapping you orally in section of exam? Poor fellow
- One who is hard up‘s written article about uranium
- In the Guardian perhaps it’s socially desirable to be a have-not!
- Beggar you heard is wrapped in Telegraph?
- Father's state: about to turn bankrupt
Buddy explains!

The straight part
We know that "down-and-out" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case down-and-out = pauper.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PAUPER mean?
PAUPER noun- One who is extremely poor.
- One living on or eligible for public charity.