Cryptic crossword clue
University upset about son causing bother 8

The most common and most likely answer to this crossword clue is the 8 letter word UNSETTLE

I've seen this crossword clue in Financial Times
U
N
S
E
T
T
L
E


Buddy explains!

The straight part
We know that "bother" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case bother = unsettle.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does UNSETTLE mean?

UNSETTLE verb
  1. To make upset or uncomfortable
  2. To bring into disorder or disarray

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