Cryptic crossword clue
Unnerved, run off to East 2nd Avenue 7

The most common and most likely answer to this crossword clue is the 7 letter word ALAMEDA

I've seen this crossword clue in Financial Times
A
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Buddy explains!

The straight part
We know that "Avenue" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case avenue = alameda.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ALAMEDA mean?

ALAMEDA noun
  1. A tree-lined avenue in Spain or Portugal.

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