The most common and most likely answer to this crossword clue is the 10 letter word EMASCULATE
I've seen this crossword clue in The Guardian
E
M
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More clues leading to the result EMASCULATE
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does EMASCULATE mean?
EMASCULATE verb- To deprive of virile or procreative power; to castrate, to geld.
- To deprive of masculine vigor or spirit; to weaken; to render effeminate; to vitiate by unmanly softness.
- Of a flower: to deprive of the anthers.
- Deprived of virility or vigor; unmanned, weak.