Cryptic crossword clue
Unsightly condition Isaac Newton bears 4

The most common and most likely answer to this crossword clue is the 4 letter word ACNE

A
C
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The straight part
We know that "Unsightly condition" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case unsightly condition = acne.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ACNE mean?

ACNE noun
  1. A skin condition, usually of the face, that is common in adolescents. It is characterised by red pimples, and is caused by the inflammation of sebaceous glands through bacterial infection.
  2. A pattern of blemishes in an area of skin resulting from the skin condition.

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