Cryptic crossword clue
Unstable type, artist taking drug, one with nothing, is given therapy inside 12

The most common and most likely answer to this crossword clue is the 12 letter word RADIOISOTOPE

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Buddy explains!

The straight part
We know that "Unstable type" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case unstable type = radioisotope.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RADIOISOTOPE mean?

RADIOISOTOPE noun
  1. A radioactive isotope of an element

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