Cryptic crossword clue
Untimely end of Doctor, trapped by River Song after fashionable operation 11

The most common and most likely answer to this crossword clue is the 11 letter word INOPPORTUNE

I
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Buddy explains!

The straight part
We know that "Untimely" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case untimely = inopportune.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INOPPORTUNE mean?

INOPPORTUNE adjective
  1. Unsuitable for some particular purpose
  2. At an inconvenient or inappropriate time

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