Cryptic crossword clue
Unusual development in intro to tune by Muse, English rock band 13

The most common and most likely answer to this crossword clue is the 13 letter word TERATOGENESIS

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Buddy explains!

The straight part
We know that "Unusual development" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case unusual development = teratogenesis.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TERATOGENESIS mean?

TERATOGENESIS noun
  1. The development of congenital malformations.

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