The most common and most likely answer to this crossword clue is the 5 plus 3 letter word CLEAR OFF
I've seen this crossword clue in The Times
C
L
E
A
R
O
F
F
More clues leading to the result CLEAR OFF
- Go away untroubled on holiday
- Force Alf when drunk to go way
- Unusual for a clef to get lost
- Leave fair, out of sorts
- Close by organ having a bad smell? Shift!
- Go away when it’s cloudless on holiday
- Move all the fielders to the onside? Get lost!
- Musical character, holding discussions, about to make tracks
- Go away from bad oracle and a couple of females
- Repay debt in full and move on
Buddy explains!

The straight part
We know that "get lost" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case get lost = clear off.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.