The most common and most likely answer to this crossword clue is the 8 letter word KERATOSE
K
E
R
A
T
O
S
E
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The straight part
We know that "with hard inner framework" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case with hard inner framework = keratose.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.