Cryptic crossword clue
Unusually quaint limits managed, in grand scheme to reduce infection 12

The most common and most likely answer to this crossword clue is the 12 letter word QUARANTINING

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Buddy explains!

The straight part
We know that "scheme to reduce infection" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case scheme to reduce infection = quarantining.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does QUARANTINING mean?

QUARANTINING verb
  1. To retain in obligatory isolation or separation, as a sanitary measure to prevent the spread of contagious disease.
  2. To put in isolation as if by quarantine

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