Cryptic crossword clue
Unwelcomely occupy island home with fine interior 6

The most common and most likely answer to this crossword clue is the 6 letter word INFEST

I've seen this crossword clue in The Daily Telegraph
I
N
F
E
S
T

Buddy explains!

The straight part
We know that "Unwelcomely occupy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case unwelcomely occupy = infest.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INFEST mean?

INFEST noun
  1. Hostility.
INFEST verb
  1. To inhabit a place in unpleasantly large numbers; to plague, harass.
  2. (of a parasite) To invade a host plant or animal.
INFEST adjective
  1. Mischievous; hurtful; harassing.

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