Cryptic crossword clue
Upend quilt Dotty made five times 10

The most common and most likely answer to this crossword clue is the 10 letter word QUINTUPLED

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does QUINTUPLED mean?

QUINTUPLED verb
  1. To multiply something (or be multiplied) by five

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