Cryptic crossword clue
Upfront ambassador to oppose such a sale system 4-3-7

The most common and most likely answer to this crossword clue is the 4 plus 3 plus 7 letter word OVER THE COUNTER

I've seen this crossword clue in Independent
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OVER THE COUNTER mean?

OVER THE COUNTER adjective
  1. Legal for sale or distribution without the requirement of a prescription (of medicine and other treatments); abbreviated as OTC.
  2. Involving direct interaction between two parties without an intermediary. Thus, any market where items such as stocks or currency are bought and sold at a distance, rather than on the exchange.

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