Cryptic crossword clue
Upper-class girl set about in spreading hypocrisy 13

The most common and most likely answer to this crossword clue is the 13 letter word DISSIMULATION

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Buddy explains!

The straight part
We know that "hypocrisy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case hypocrisy = dissimulation.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DISSIMULATION mean?

DISSIMULATION noun
  1. The act of concealing the truth; hypocrisy or deception.
  2. Hiding one's feelings or intentions.

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