Cryptic crossword clue
Uprooted old Irishman, ready to drop trousers 10

The most common and most likely answer to this crossword clue is the 10 letter word EXTIRPATED

I've seen this crossword clue in The Guardian
E
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Buddy explains!

The straight part
We know that "Uprooted" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case uprooted = extirpated.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EXTIRPATED mean?

EXTIRPATED verb
  1. To clear an area of roots and stumps.
  2. To pull up by the roots; uproot.
  3. To destroy completely; to annihilate.
  4. To surgically remove.
EXTIRPATED adjective
  1. (of a species) Locally extinct (though alive elsewhere).

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