The most common and most likely answer to this crossword clue is the 6 letter word GUTTED
I've seen this crossword clue in The Daily Telegraph
G
U
T
T
E
D
Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does GUTTED mean?
GUTTED verb- To eviscerate.
- To remove or destroy the most important parts of.
- Eviscerated.
- With the most important parts destroyed (often by fire), removed or rendered useless.
- Having a gut or guts.
- Deeply disappointed; annoyed; down.